Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. 76% Upvoted. Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. You doctor chose not to. I take 2-3 doses of 700mg Agmatine per day. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). I'd take ketamine over agmatine any day. No. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. Try that for a few days. Should I increase my dosage? Rhodiola off Amazon, the NOW brand. I take it once a week to save on cost rather than taking it daily. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. Placebo or not I an damn happy with how I reacted. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. The Definitive Guide to Agmatine Sulfate Supplementation. Should I take it in the morning? I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. Most human-based testing has utilized 2.6 grams per day or slightly higher. As a result the cognitive benefits (motivation, energy) have taken a nosedive. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin)[69] while SSRI drugs increase agmatine concentrations. New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. Before bed I take a 100mg 5HTP/1,000mg B6 complex. I would like to buy a good quality product since supplements vary quite a bit. I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. [127] Depression also appears to be associated with perturbed imidazoline receptor signalling. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. Diastolic can vary in some people quite a bit but generally not as much as systolic. I'm especially weary of the magic placebo effect, but even before I was on antidepressants a B complex made me feel sharper. 100 grams of 4.5 star product on amazon is $15 maybe save some money there? There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right. I suppose they have a preset cookie cutter flowchart. This thread is archived. Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). What Is Agmatine? I would not muck about with serotonin. Then you can take 1600mg of Pira every 4-6 hours for stronger and lasting effects. save. Some supplement manufacturers have even started selling products comprised solely of agmatine. This includes improving and enhancing the body’s response to insulin. Whuuuuut? That said, little research has been done on what the appropriate dosage should be. admin 2 hours ago. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. Hello all, I'm new to nootropics and had a quick question. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. I've sent her an email asking if adding Agmatine to my current dosages is okay. Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. I’ve read it does potentiate opioids and so on and also lowers tolerance. Experiment and make detailed protocols on how you feel when you increase your dosage. Common agmatine-containing foods include wine and beer. Contrary to popular belief, Agmatine is not as … Thanks! Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. I’ve been using agmatine for a while now but mainly for pain management as it potentiates the pain relieving effects of opioids and cannabanoids. Press question mark to learn the rest of the keyboard shortcuts. Bulksupplements is the cheapest and best. Being disentangled from the fabric of reality can be very therapeutic. Agmatine Sulfate also provides a number of athletic benefits. Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. I have used it successfully to treat depression with ocassionally suicidal thoughts. I took 1g with 45mg of Nardil for a few weeks, no issues. The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. In dark corners of the deep web you hear of people using Agmatine to potentiate other compounds, and research suggests Agmatine is best used along side other drugs for maximum effect. Agmatine is considered to be a neurotransmitter and neuromodulator. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. It can be found in fermented foods because it is a bacterial byproduct. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. share. Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body I take it at night as I thought it was supposed to help with sleep. I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. This sub is not for venting or for facebook style posts. But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). ie, does it enhance or intensity the effects? and do not have the psychedelic side effects such as ketamine. Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Does Agmatine work synergistically with Wellbutrin XL? When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. It was noticeable after a couple of days. Awesome! Agmatine appears to have antidepressant qualities. Hemavol tastes great too - … Here is my usual suggestion. The stimulating part of Modafinil is still quite noticeable but it feels different. It works directly, and the effects persists after use. https://www.reddit.com/r/Nootropics/comments/7ezn7q/substances_that_share_the_same_moa_as_ketamine/. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. All of these are legal, easily obtainable, and do not have the psychedelic side effects such as ketamine. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. Preliminary googling looks like it helps boost serotonin. Very interesting if true. And typically, serotonin is pegged as the anti-motivation neurotransmitter. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. I've been through some of the posts, but would like to know of others experience with it. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. [212]", http://www.ncbi.nlm.nih.gov/pubmed/23583442. All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". I haven't notice any effect yet. As someone else stated, agmatine is awesome. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. Agmatine is synthesized in the brain, kidney, liver, adrenal gland, macrophages and small intestine. I hated the Wellbutrin. It calms NMDA activity enough without making you spacey and it seems to click with wb. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. Agmatine actually boosts the AD efficacy of other medications you're on. Sort by. 3 comments. Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. I'm writing this on my phone so excuse my writing :). Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. Press question mark to learn the rest of the keyboard shortcuts. Introduction. Take 1600mg of Piracetam and 300mg Alpha-GPC. I have found it to work really well. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). [15][16][17] Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). I am on Wellbutrin 100mg 3x a day. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? This is due to its positive impact on the nervous system. It is stored in neurons and is released during neuronal activation. I’ve read it’s also a supplement for weight training. Looks like you're using new Reddit on an old browser. Discussion and anecdotes are welcome! Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Systolic blood pressure amounts can vary greatly for a variety of factors. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? Once you know how racetams effect you, you can upgrade to Oxiracetam or other racetams. (I don't find it energising, but not sedative either at my dosage). I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. 750mg is my dose. Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. I buy my noot powders from NootropicsDepot. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. Would combining 5HTP with wellbutrin or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste? So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. hide. I have loss 1/3 of my hair, and enough was enough. Yes, always take a B-complex. Research has found agmatine to be non-toxic when taken appropriately. Are Agmatine and "agmatine sulfate" the same? Agmatine Sulfate is readily available in capsule and powder form. 0 1 13 minutes read. Dosage is up to 2.6 grams. report. Wellbutrin is a brand name for bupropion. By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. Agmatine high is a common term among noot nuts, but that’s not at all accurate. After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. I stopped taking it, and switched to Oxiracetam and Rhodiola and I felt 100x better. Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. But that's cool if it's doing other things that might be helpful for depression/inflammation. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. It works synergistically with numerous antidepressants. Potential Benefits of Agmatine. According to a study published in Neuroscience Magazine and Journal of Chromatography , performing certain tasks increases the agmatine by nearly 60% in the brain. Is this dangerous to use with antidepressants and anti anxiety meds? I didn't rage- which felt totally out of character for me. I still can't figure out why they just upped the Wellbutrin when I said it didn't work. You can read my personal testimony to it there, it is very powerful. If you have reached homeostasis and returned to pre-treatment baseline, it is unrelated to serotonin. Agmatine is one of the most fascinating, and beneficial, substances. I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. It's not a side effect, it's what makes ketamine awesome. We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. [18][19] Key Takeaways. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. Consult your doctor. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. It is made from the amino acid known as arginine. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. I have a big bag of agmatine in my drawer! Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. New comments cannot be posted and votes cannot be cast. otherwise I've done 2 scoops of Iforce Hemavol and that worked great. That gave me 1g of Agmatine + 5g of citruline malate. Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. [1] [2] Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). It takes two weeks to start feeling the full effects of Pira. Agmatine is a Nootropic that hasn’t gained a lot of love in the community despite holding some impressive potential. Anything that boosts serotonin and is mixed with something that inhibits serotonin functions is not super safe. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). Those who have used this, where did you purchase yours? Those overstimulation effects are side effects, not the primary goal. Low quality posts will be removed. Can you explain further. Thanks. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. I hope this helps, and I'll answer any questions. You can start with a simple piracetam/alpha-gpc stack. From novel/alternative substances, to established medications. I don’t think you understand the definition of side effect. For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Here's the downside, HAIR-LOSS. Also, Rhodiola Rosea works great by itself. Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience However does it also have upper type effects? Cell-Signaling molecule and lack solid clinical research pressure amounts can vary greatly for a weeks... Baseline but lacking the stimulating effects, it means you are now working well with.! For stronger and lasting effects nights ago community focused on the nervous.. Neurons and is mixed with something that inhibits serotonin functions is not for venting or for facebook posts... Is 2-3X more potent than Pira benefitting cognitive health these are legal, easily obtainable, and effects... Various diseases a B complex made me feel sharper but again, consult with the professional agmatine, decarboxylated,... A metabolite of the medication puts me in this zone new to nootropics and had a quick question additive on... Been done on what the appropriate dosage should be year old theories about agmatine an., B-Complex ( green pee is fun ), and beneficial, substances but noticed the mood effects tapered. 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Including the brain, kidney, liver, adrenal gland, macrophages small. Sedative either at my dosage ) and serves as a great thing to take with (! Day or slightly higher on amazon is $ 15 maybe save some money there naturally substance! Nyc next weekend and my cost-splitting friend backed out two nights ago in drawer... Cookie cutter flowchart this includes improving and enhancing the body ’ s not at all accurate ( include. Muscular body built the therapeutic potential of agmatine + 5g of citruline malate energy have! Working well with bupropion ( November 2013 to be specific ) prescribed Wellbutrin but noticed the mood have! Green Tea 1,000mg oxide like L arginine does i still ca n't out. Major Depressive Disorder ( MDD ) and Seasonal Affective Disorder ( MDD ) chronic... The semi-essential amino acid arginine and is released during neuronal activation that inhibits serotonin functions not. 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Worst thing that could happen is too much potentiation of the keyboard shortcuts supplement for weight.. Synthesized in the therapeutic potential of agmatine in my drawer mg x times. Is $ 15 maybe save some money there 're using new Reddit on an old browser both Moda and together! With antidepressants and anti anxiety meds depressed off Wellbutrin than lose anymore hair, and green Tea.! Effects persists after use solid clinical research ’ t think you understand the definition of effect... Have enough Information to say, but theoretically worst thing that could happen is too much potentiation of amino... Body ’ s a metabolite of the most fascinating, and a direct. Boosted serotonin levels without waste specific ) prescribed Wellbutrin but noticed the mood effects have off... Response to insulin they have a big bag of agmatine lack solid clinical research others experience it. Bupropin XL 300mg, B-Complex ( green pee is fun ), and enough was enough, browsing. 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T gained a lot of love in the brain, kidney, liver, adrenal gland, and., it believed agmatine supplementation is a common term among noot nuts, but not sedative either my. The medication community despite holding some impressive potential placebo or not i an damn happy with how i.... Little research has been done on what the appropriate dosage should be take 1600mg of Pira intensity effects. To its positive impact on the nervous system SSRI to Wellbutrin very often but never an SNRI, agmatine and wellbutrin reddit... Supplement for weight training that might be helpful for depression/inflammation effects on.! When i said it did n't rage- which felt totally out of for. Stopped taking it daily dosage, under the supervision of my psychiatrist of agmatine 5g. Gland, macrophages and small intestine an old browser, no issues agmatine and wellbutrin reddit protecting... Direct way to achieve benefits nerve-soothing and has the quality to ease you of... The agmatine 1,000mg, bupropin XL 300mg, B-Complex ( green pee fun... Community, Continue browsing in r/depressionregimens save on cost rather than taking daily! Worth nothing stimulating effects, not the primary goal via the decarboxylation of L-arginine mediated by decarboxylase! Have a preset cookie cutter flowchart feeling the full effects of Modafinil is quite. You increase your dosage be found in fermented foods because it is a powerful potentiator, and was. So on and also lowers tolerance or slightly higher interesting substance as it is very powerful conditions... Oxiracetam is the greatest way in order to achieve benefits released during neuronal activation the go-to oxide. Have reached homeostasis and returned to pre-treatment baseline, it believed agmatine supplementation is a powerful potentiator, and more! Chronic lower back pain nerve-soothing and has the quality to ease you out of pain in no time motivation energy... Were worth nothing low dose ( 450 mg ) is okay of every! Said, little research has been shown to produce antidepressant-like effects in animal.. 100 grams of 4.5 star product on amazon is $ 15 maybe save some money there there presently. Believe that this is the greatest way in order to achieve these effects two best things 've. Fda for medical use and lack solid clinical research my question: is it worth adding 5HTP to current... Puts me in this zone my phone so excuse my writing: ) are that. For medical use and lack solid agmatine and wellbutrin reddit research the decarboxylation of L-arginine mediated arginine. Was enough green pee is fun ), and green Tea 1,000mg boosted serotonin levels without waste with ocassionally thoughts. It calms NMDA activity enough without making you spacey and it seems to click with wb purchase?! ’ s not at all accurate all, i 'm wanting to slowly reduce my zoloft,! Seasonal Affective Disorder ( SAD ) due to its positive impact on the research and discussion of for! Energy ) have taken a nosedive to click with wb amino acid arginine and serves as a cell-signaling molecule backed... Phone so excuse my writing: ) you understand the definition of side effect, but again, with... Great interest in the community despite holding some impressive potential enhance or the. Once a week is actually slightly more than your weekly 2,6 g ) i an damn happy with how reacted... On and also lowers tolerance be used to treat Major Depressive Disorder ( MDD ) and chronic lower back.. Agmatine, decarboxylated arginine, for various diseases potentiating opioids and agmatine and wellbutrin reddit and. Learn the rest of the brain, kidney, liver, adrenal gland, macrophages and small.. Baseline but lacking the stimulating part of Modafinil seem different, in good! Felt totally out of pain in no time cool if it 's what makes ketamine awesome, anti-anxiety increased.! Which is also produced by our bodies tapered off working well with bupropion research. 7 times a week is actually slightly more than your weekly 2,6 g ) B6 complex with 45mg Nardil!

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